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R Luise Krauth-Siegel Selected Research

trypanothione reductase

9/2019Targeting a Large Active Site: Structure-Based Design of Nanomolar Inhibitors of Trypanosoma brucei Trypanothione Reductase.
11/2008Diaryl sulfide-based inhibitors of trypanothione reductase: inhibition potency, revised binding mode and antiprotozoal activities.
11/2005Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.
7/2005Inhibitors of Trypanosoma cruzi trypanothione reductase revealed by virtual screening and parallel synthesis.
9/2002Coupling of a competitive and an irreversible ligand generates mixed type inhibitors of Trypanosoma cruzi trypanothione reductase.

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R Luise Krauth-Siegel Research Topics

Disease

14African Trypanosomiasis (Nagana)
09/2019 - 03/2002
8Chagas Disease (American Trypanosomiasis)
09/2019 - 09/2002
3Trypanosomiasis
10/2019 - 12/2011
2Neoplasms (Cancer)
10/2019 - 01/2013
2Leishmaniasis
09/2019 - 04/2003
2Malaria
12/2009 - 01/2005
1Fever (Fevers)
01/2020
1Infections
11/2019
1Neglected Diseases
01/2017
1Inflammation (Inflammations)
12/2011

Drug/Important Bio-Agent (IBA)

5Proteins (Proteins, Gene)FDA Link
01/2020 - 05/2002
5Cysteine (L-Cysteine)FDA Link
10/2019 - 02/2003
5trypanothione reductaseIBA
09/2019 - 09/2002
5Glutathione (Reduced Glutathione)IBA
10/2008 - 02/2003
4PeroxidasesIBA
10/2008 - 02/2003
4SelenocysteineIBA
10/2008 - 02/2003
3trypanothioneIBA
10/2019 - 04/2003
3Pharmaceutical PreparationsIBA
10/2017 - 01/2005
2Biological ProductsIBA
10/2019 - 12/2011
2dithiolIBA
11/2010 - 01/2005
2EnzymesIBA
11/2008 - 04/2003
2ThioredoxinsIBA
01/2005 - 11/2003
1LactonesIBA
10/2019
1Sulfhydryl Compounds (Thiols)IBA
10/2019
1SesquiterpenesIBA
10/2019
1falcipain 2IBA
01/2017
1rhodesainIBA
01/2017
1Peptides (Polypeptides)IBA
01/2017
1benzonidazole (benznidazole)IBA
05/2016
1Eflornithine (Ornidyl)FDA Link
02/2014
1NifurtimoxIBA
02/2014
1cynaropicrinIBA
11/2013
1NSC 23175IBA
01/2013
1DNA (Deoxyribonucleic Acid)IBA
01/2013
1xanthatinIBA
12/2011
1Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA
12/2011
1Prostaglandins EIBA
12/2011
1GlutaredoxinsIBA
11/2010
1LigandsIBA
06/2006
1PalladiumIBA
06/2006
1ThiosemicarbazonesIBA
06/2006
1Mannich BasesIBA
11/2005
1hydroxyacylglutathione hydrolaseIBA
05/2004
1PlatinumIBA
09/2002
1tryparedoxinIBA
05/2002

Therapy/Procedure

2Therapeutics
02/2014 - 01/2013
1Transcutaneous Electric Nerve Stimulation (TENS)
11/2019
1Radiotherapy
01/2013
1Drug Therapy (Chemotherapy)
03/2002